Advanced rheumatoid arthritis, illustration 插畫檔

Illustration showing the late-stage pathological changes of a joint affected by rheumatoid arthritis. The articular cartilage exhibits severe destruction with marked surface erosion and defects, accompanied by significant narrowing of the joint space. Within the joint cavity, extensive proliferative synovium forms a pannus that further erodes the cartilage and subchondral bone. The subchondral bone showing cystic changes and osteoporosis, characterized by sparse trabeculae, reflecting the structural bone destruction induced by chronic inflammation