Diabetic cataract pathogenesis, illustration 插畫檔

Illustration of the pathogenesis of diabetic cataract. Hyperglycaemia facilitates glucose entry into the lens, where it is converted to sorbitol via the polyol pathway under the action of aldose reductase. The accumulation of sorbitol increases osmotic pressure, leading to the influx of extracellular fluid and oedema of lens fibres. Ultimately, these fibres undergo swelling, rupture and disintegration, resulting in lens opacification