Osteoarthritis progression, illustration 插畫檔

Illustration showing four sequential stages of articular cartilage damage during osteoarthritis progression, arranged from left to right. The leftmost panel displays a normal knee joint surface characterized by smooth and intact articular cartilage overlying the subchondral bone. The first stage reveals mild surface fibrillation and roughening of the cartilage. In the second stage, cartilage fissures deepen and extend toward the subchondral bone, accompanied by focal cartilage delamination. The third stage showing full-thickness cartilage loss with complete exposure of the subchondral bone, which exhibits cystic changes and sclerosis