RAGE Receptor, illustration 插畫檔

Illustration of the extracellular V (orange), C1 (magenta) and C2 (cyan) domains of the receptor for advanced glycation endproducts (RAGE). This transmembrane protein belongs to the immunoglobulin superfamily and is able to bind to multiple molecules. Binding results in a signal cascade that causes pro-inflammatory gene activation. The expression of RAGE is stimulated by cellular stresses, such as inflammation, and so this leads to a positive feedback cycle that results in chronic inflammation. RAGE is involved in the pathogenesis of a number of diseases including diabetes, Alzheimer's disease and cancers